Local Antibiotic Therapy Was Not Given Enough Space

Local antibiotic therapy in osteomyelitis.

The local delivery of antibiotics in the treatment of osteomyelitis has been used safely and effectively for decades. Multiple methods of drug delivery have been developed for the purposes of both infection treatment and prophylaxis. The mainstay of treatment in this application over the past 20 years has been non-biodegradable polymethylmethacrylate, which has the advantages of excellent eluti...

Legislation Alone is Enough to Combat Antibiotic Misuse? Certainly Not!

Not Enough Points Is Enough

Models of the untyped λ-calculus may be defined either as applicative structures satisfying a bunch of first order axioms, known as “λ-models”, or as (structures arising from) any reflexive object in a cartesian closed category (ccc, for brevity). These notions are tightly linked in the sense that: given a λ-model A, one may define a ccc in which A (the carrier set) is a reflexive object; conve...

When Enough Is Not Enough

People are often exposed to more information than they can actually remember. Despite this frequent form of information overload, little is known about how much information people choose to remember. Using a novel “stop” paradigm, the current research examined whether and how people choose to stop receiving new—possibly overwhelming—information with the intent to maximize memory performance. Pa...

Adhesivity Is Not Enough: Local Church-Rosser Revisited

Adhesive categories provide an abstract setting for the doublepushout approach to rewriting, generalising classical approaches to graph transformation. Fundamental results about parallelism and confluence, including the local Church-Rosser theorem, can be proven in adhesive categories, provided that one restricts to linear rules. We identify a class of categories, including most adhesive catego...